|
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.
|
14744462 |
2004 |
|
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5-HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression.
|
20047709 |
2010 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder.
|
24801750 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population.
|
19428704 |
2009 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several studies in major depression have implicated a role of the serotonin receptor gene (HTR2A) in treatment response to antidepressants.
|
22006095 |
2013 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-HT2A and 5-HT3A serotonin receptors in the pathophysiology of major depression.
|
28125323 |
2017 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD.
|
23547754 |
2013 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
5-HT2A receptor -1438 G/A polymorphism and serotonergic antidepressant-induced sexual dysfunction in male patients with major depressive disorder: a prospective exploratory study.
|
22612784 |
2012 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.
|
19937159 |
2010 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: a meta-analysis.
|
25108775 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression.
|
11121191 |
2000 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HTR2A-1438A/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: a meta-analysis.
|
23404241 |
2013 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: a meta-analysis.
|
25108775 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
5-HT2A receptor -1438 G/A polymorphism and serotonergic antidepressant-induced sexual dysfunction in male patients with major depressive disorder: a prospective exploratory study.
|
22612784 |
2012 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression.
|
17221840 |
2007 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression.
|
15469201 |
2004 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variation in the 5-HT2A receptor gene may play a role in the development of major depression with seasonal pattern and support the existence of a genetic and etiological heterogeneity underlying the diagnosis of major depression.
|
11317230 |
2001 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate the influence of a HTR2A polymorphism on aspects of somatization in major depression, which co-occurs with an unfavorable antidepressant treatment outcome.
|
21838737 |
2011 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
|
21136126 |
2010 |